Effects of Extracts Derived from Roots and Stems of Chelidonium majus L. on Oxidative Stress Biomarkers in the Model of Equine Plasma

Greater celandine (Chelidonium majus L., Papaveraceae) is a perennial herbaceous plant, with an upright and spreading stem, large leaves, yellow flowers collected on the tops of stems in rare umbel inflorescence. The main aim study was assessment oxidative stress biomarkers [2-thiobarbituric acid reactive substances (TBARS), carbonyl derivatives content protein modification (OMP), total antioxidant capacity (TAC)] also activity enzymes (catalase, ceruloplasmin) equine plasma after treatment by extracts derived from roots C. rural urban agglomerations. Plant materials were natural habitats territory Kartuzy district Pomeranian province (northern part Poland). Our results demonstrated that statistically significant reductions lipid peroxidation byproducts noted incubation both (by 35 %, p <0.05) 34 agglomerations compared to control samples. Stem reduced TBARS levels, but only areas; decrease 21 observed lowest values aldehydic OMP areas. On other hand, levels ketonic significantly increased areas samples, contrast areas, where there reduction 15 p<0.05) A increase TAC root stem highest 66.7 found be most effective increasing catalase 115 <0.05). Both caused ceruloplasmin levels. These vitro studies indicate this plant are source antioxidants could prevent progression various disorders stress. However, proportions secondary metabolites responsible for currently unclear. Therefore, further needed isolate identify compounds present extracts. Screening biological activities including essential may searching preventive agents pathogenesis some metabolic diseases.